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Everything you need to know.

The importance of publications

The international scientific community is informed about the ongoing clinical achievements, by scientific articles (published in esteemed scientific journals). The importance of these articles and the clinical research described, is constantly assessed by 2 and/or 3 specialised scientists/professors from all around the world before these articles be published. That way they ensure that the particular article is unique and offers to the scientific community something new and innovative/pioneering.

The publication of our scientific articles, especially in internationally esteemed journals is a top honor for Eugonia's team. Our publications offer to the international scientific community new expertise regarding the protocols for women with poor response, PCOS, polycystic ovaries. These articles, for which we are very proud, reflect the deep knowledge of the scientific field, the best scientific and technological training of our team and the constant "race" by all the members of Eugonia( physicians, midwifes, embryologists) for an ongoing improvement regarding the treatment referred to the couples visiting our center.

Scientific papers published in international scientific journals

The importance of follicular flushing in optimizing oocyte retrieval.
George Lainas Trifon Lainas and Efstratios Kolibianakis
CURRENT OPINION Obstet Gynecol 2023,35:000–000 DOI:10.1097/GCO.0000000000000870

The HERA (Hyper-response Risk Assessment) Delphi consensus definition of hyper-responders for in-vitro fertilization.
Feferkorn I, Ata B, Esteves SC, La Marca A, Paulson R, Blockeel C, Conforti A, Fatemi HM, Humaidan P, Lainas GT, Mol BW, Norman RJ, Orvieto R, Polyzos NP, Santos-Ribeiro S, Sunkara SK, Tan SL, Ubaldi FM, Urman B, Velasco JG, Weissman A, Yarali H, Dahan MH
.J Assist Reprod Genet. 2023 Mar 18. doi: 10.1007/s10815-023-02757-4. Online ahead of print.PMID: 36933094
See the publication

Follitropin Alpha for assisted reproduction: an analysis based on a non-interventional study in Greece.
Fragoulakis V, Mantis A, Christoforidis N, Dovas D, Deftereos S, Lainas T, Mantoudis E, Paraschos T, Sakellariou D, Makrakis E.
Curr Med Res Opin. 2022 Dec;38(12):2227-2235. doi: 10.1080/03007995.2022.2131303. Epub 2022 Oct 13.PMID: 36193626
See the publication

The Maribor consensus: report of an expert meeting on the development of performance indicators for clinical practice in ART.
ESHRE Clinic PI Working Group, Vlaisavljevic V, Apter S, Capalbo A, D'Angelo A, Gianaroli L, Griesinger G, Kolibianakis EM, Lainas G, Mardesic T, Motrenko T, Pelkonen S, Romualdi D, Vermeulen N, Tilleman K.
Hum Reprod Open. 2021 Jul 3;2021(3):hoab022.
See the publication

Reply: Questionable recommendation for LPS for IVF/ICSI in ESHRE guideline 2019: ovarian stimulation for IVF/ICSI.
Broekmans F, Humaidan P, Lainas G, Töyli M, Le Clef N, Vermeulen N. Hum
Reprod Open. 2021 Mar 3;2021(1):hoab006.
See the publication

How frequent is severe ovarian hyperstimulation syndrome after GnRH agonist triggering in high-risk women? A systematic review and meta-analysis.
Ioannidou PG, Bosdou JK, Lainas GT, Lainas TG, Grimbizis GF, Kolibianakis EM.
Reprod Biomed Online. 2021 Mar;42(3):635-650.
See the publication

Erratum: ESHRE guideline: ovarian stimulation for IVF/ICSI.
ESHRE Guideline Group on Ovarian Stimulation, Bosch E, Broer S, Griesinger G, Grynberg M, Humaidan P, Kolibianakis E, Kunicki M, Marca A, Lainas G, Clef NL, Massin N, Mastenbroek S, Polyzos N, Sunkara SK, Timeva T, Töyli M, Urbancsek J, Vermeulen N, Broekmans F.
Hum Reprod Open. 2020 Dec 29;2020(4):hoaa067.
See the publication

Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?
Bosdou JK, Anagnostis P, Lainas GT, Kolibianakis EM.
Curr Pharm Des. 2020;26(43):5551
See the publication

Is the probability of pregnancy after ovarian stimulation for IVF associated with serum estradiol levels on the day of triggering final oocyte maturation with hCG? A systematic review and meta-analysis.
Karatasiou GI, Bosdou JK, Venetis CA, Zepiridis L, Chatzimeletiou K, Tarlatzi TB, Lainas G, Tarlatzis BC, Grimbizis G, Kolibianakis EM.
J Assist Reprod Genet. 2020 Jul;37(7):1531-1541.
See the publication

Risk of gestational diabetes mellitus in women achieving singleton pregnancy spontaneously or after ART: a systematic review and meta-analysis.
Bosdou, J.K., Anagnostis, P., Goulis, D.G., Lainas, G.T., Tarlatzis, B.C., Grimbizis, G.F. and Kolibianakis, E.M.
Hum Reprod Update. 2020 Jun 18;26(4):514-544.
See the publication

A decision-making algorithm for performing or cancelling embryo transfer in patients at high-risk for ovarian hyperstimulation syndrome (OHSS) after triggering final oocyte maturation with hCG.
Lainas GT,  Lainas TG, Sfontouris IA, Venetis CA, Kyprianou MA, Petsas GK, Tarlatzis BC, Kolibianakis EM.
Human Reproduction Open 2020

ESHRE guideline: ovarian stimulation for IVF/ICSI.
Ovarian Stimulation, T.E.G.G.O., Bosch, E., Broer, S., Griesinger, G., Grynberg, M., Humaidan, P., Kolibianakis, E., Kunicki, M., La Marca, A., Lainas, G. and Le Clef, N.,
Human Reproduction Open, 2020(2), p.hoaa009.
See the publication

Association between body mass index and oocyte maturation in patients triggered with GnRH agonist who are at high risk for severe ovarian hyperstimulation syndrome: an observational cohort study
Lainas GT,  Lainas TG, Sfontouris IA, Venetis CA, Bosdou JK, Chatzimeletiou A, Grimbizis GF, Tarlatzis BC, Kolibianakis EM.
Reproductive BioMedicine Online, 2019, 40(1), 168-175.
See the publication

Is oocyte maturation rate associated with triptorelin dose used for triggering final oocyte maturation in patients at high risk for severe ovarian hyperstimulation syndrome?
Lainas GT, Lainas TG, Sfontouris IA, Chatzimeletiou A, Venetis CA, Bosdou JK, Tarlatzis BC, Grimbizis GF, Kolibianakis EM.
Human Reproduction, 2019, 34(9), 1770-1777.
See the publication

Ultrasound and hematological early-luteal-phase predictors of severe ovarian hyperstimulation syndrome in high-risk patients following triggering of final oocyte maturation with human chorionic gonadotropin.
Sfontouris I, Lainas G, Lainas T, Venetis C, Makris A, Tarlatzis B, Kolibianakis E.
Ultrasound Obstet Gynecol. 2018 Oct;52(4):556.
See the publication

Complex chromosomal aberrations in a fetus originating from oocytes with smooth endoplasmic reticulum (SER) aggregates.
Sfontouris IA, Lainas GT, Lainas TG, Faros E, Banti M, Kardara K, Anagnostopoulou K, Kontos H, Petsas GK, Kolibianakis EM.
Syst Biol Reprod Med. 2018 Aug;64(4):283-290 .
See the publication

Ultrasound and hematological changes during early luteal phase in women at high risk for developing ovarian hyperstimulation syndrome.
Lainas GT, Lainas TG, Venetis CA, Sfontouris IA, Zorzovilis IZ, Alexopoulou E, Tarlatzis BC, Kolibianakis EM.
Ultrasound Obstet Gynecol. 2018 Jan;51(1):126-133.
See the publication

Blastocyst utilization rates after continuous culture in two commercial single-step media: a prospective randomized study with sibling oocytes.
Sfontouris IA, Kolibianakis EM, Lainas GT, Venetis CA, Petsas GK, Tarlatzis BC, Lainas TG.
J Assist Reprod Genet. 2017 Oct;34(10):1377-1383.
See the publication

Blastocyst Development in a Single Medium Compared to Sequential Media: A Prospective Study with Sibling Oocytes.
Sfontouris IA, Kolibianakis EM, Lainas GT, Petsas GK, Tarlatzis BC, Lainas TG.
Reproductive Sciences, 2017 Sep;24(9):1312-1318.                        
See the publication

Basal serum progesterone and history of elevated progesterone on the day of hCG are significant predictors of late follicular progesterone elevation in GnRH antagonist IVF cycles.
Venetis CA, Kolibianakis EM, Bosdou JK, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Human Reproduction, 2016 Aug;31(8):1859-65.
See the publication

Reply: Modified natural cycles for poor responders: addressing misconceptions and fallacies.
Kolibianakis EM, Lainas TG, Venetis CA.
Hum Reprod. 2016 Jan;31(1):222-3.
See the publication

Live birth rates after modified natural cycle compared with high-dose FSH stimulation using GnRH antagonists in poor responders.
Lainas TG, Sfontouris IA, Venetis CA, Lainas GT, Zorzovilis IZ, Tarlatzis BC, Kolibianakis EM.
Human Reproduction 2015 Oct;30(10):2321-30.
See the publication

Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved.
Sfontouris IA, Kolibianakis EM, Lainas GT, Navaratnarajah R, Tarlatzis BC, Lainas TG.
J Assist Reprod Genet 2015 May;32(5):691-7 .
See the publication

Authors’ reply.
Lainas TG, Kolibianakis EM.
BJOG. 2015 Mar;122(4):585-6.
See the publication

Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles.
Venetis CA, Kolibianakis EM, Bosdou JK, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Hum Reprod 2015 Mar;30(3):684-91.
See the publication

Serum vascular endothelial growth factor levels following luteal gonadotrophin-releasing hormone antagonist administration in women with severe early ovarian hyperstimulation syndrome.
Lainas GT, Kolibianakis EM, Sfontouris IA, Zorzovilis IZ , Petsas GK, Lainas TG, Tarlatzis BC.
BJOG 2014 Jun;121(7):848-55.
See the publication

No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individual patient data meta-analysis.
Vergouw CG, Heymans MW, Hardarson T, Sfontouris IA, Economou KA, Ahlström A.,  Rogberg L, Lainas TG, Sakkas D, Kieslinger DC, Kostelijk EH, Hompes PG, Schats R, Lambalk CB.
Human Reproduction 2014 Mar;29(3):455-61
See the publication

Pregnancy and neonatal outcomes following luteal GnRH antagonist administration in patients with severe early OHSS.
Lainas GT., Kolibianakis EM., Sfontouris IA., Zorzovilis IZ., Petsas GK., Lainas TG., Tarlatzis BC.
Hum Reprod. 2013 Jul;28(7):1929-42.
See the publication

Non-invasive metabolomic analysis using a commercial NIR instrument for embryo selection.
Sfontouris I A., Lainas GT., Sakkas D., Zorzovilis IZ., Petsas GK., Lainas TG.
J Hum Reprod Sci. 2013 Apr;6(2):133-9.
See the publication

Outpatient management of severe early OHSS by administration of GnRH antagonist in the luteal phase: an observational cohort study.
Lainas GT, Kolibianakis EM, Sfontouris IA, Zorzovilis IZ, Petsas GK, Tarlatzi TB, Tarlatzis BC, Lainas TG.Reprod Biology  Endocrinol. 2012 Aug 31;10:69.
See the publication

Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT).
LainasTG, Sfontouris IA, Zorzovilis IZ, Petsas GK, Lainas GT, Alexopoulou E, Kolibianakis EM.
Hum  Reprod. 2010 Mar;25(3):683-9.
See the publication

Live births after management of severe OHSS by GnRH antagonist administration in the luteal phase.
Lainas TG, Sfontouris IA, Zorzovilis IZ, Petsas GK, Lainas GT, Alexopoulou E, Kolibianakis EM.
Reprod BioMed Online. 2009 Dec;19(6):789-95.
See the publication

Management of severe OHSS using GnRH antagonist and blastocyst cryopreservation in PCOS patients treated with long protocol.
Lainas TG, Sfontouris IA, Zorzovilis IZ, Petsas GK, Lainas GT, Iliadis GS, Kolibianakis EM.
Reprod BioMed Online. 2009 Jan;18(1):15-20.
See the publication

Flexible GnRH antagonist versus flare-up GnRH agonist protocol in poor responders treated by IVF: a randomized controlled trial.
LainasTG, Sfontouris IA, Papanikolaou EG, Zorzovilis IZ, Petsas GK, Lainas GT, Kolibianakis EM.
Hum Reprod. 2008 Jun;23(6):1355-8.
See the publication

Management of severe early ovarian hyperstimulation syndrome by re-initiation of GnRH antagonist.
Lainas TG, Sfontouris IA, Zorzovilis IZ, Petsas GK, Lainas GT, Kolibianakis EM.
Reprod BioMed Online.2007 Oct;15(4):408-12.
See the publication

Initiation of GnRH antagonist on Day 1 of stimulation as compared to the long agonist protocol in PCOS patients. A randomized controlled trial: effect on hormonal levels and follicular development.
Lainas TG, Petsas GK, Zorzovilis IZ, Iliadis GS, Lainas GT, Cazlaris HE, Kolibianakis EM.
Hum Reprod.  2007 Jun;22(6):1540-6.
See the publication

In a flexible antagonist protocol, earlier, criteria-based initiation of GnRH antagonist is associated with increased pregnancy rates in IVF.
Lainas T., Zorzovilis I., PetsasG., Stavropoulou G., Cazlaris H.,Daskalaki V., Lainas G., Alexopoulou E.
Hum Reprod. 2005 Sep;20(9):2426-33.
See the publication

Osseous metaplasia: case report and review.
Lainas T, Zorzovilis I, Petsas G, Alexopoulou E, Lainas G, Ioakimidis T.
Fertil Steril., 2004 Nov;82(5):1433-5.
See the publication

Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.
Lainas T, Petsas G, Stavropoulou G, Alexopoulou E, Iliadis G, Minaretzis D.
Fertil Steril. 2002 Sep;78(3):529
See the publication

Presentations in international and Greek conferences

The higher the number of times follicular flushing is repeated, the lower the probability of oocyte maturation, without an effect on fertilization and embryo cleavage.

Makris A., Lainas G., Lainas T., Sfontouris I., Apergi M., Zorzovilis I, Venetis C., Kolibianakis E.

Poster presentation: 35^th Annual Meeting of ESHRE, Vienna, Austria, 23-26 June 2019

BMI is not associated with oocyte recovery rate or maturation rate in high-risk for severe OHSS patients triggered with GnRH-agonist for final oocyte maturation.

Sfontouris I., Lainas G., Lainas T., Bosdou J., Chatzimeletiou A., Grimbizis G., Kolibianakis E.

Poster presentation: 35^th Annual Meeting of ESHRE, Vienna, Austria, 23-26 June 2019

Is oocyte maturation rate associated with the dose of triptorelin used for triggering final oocyte maturation in high-risk for severe OHSS patients, undergoing ovarian stimulation.

Lainas T.G. , Lainas G., Sfontouris I., Venetis C., Bosdou J., Chatzimeletiou A., Tarlatzis B., Grimbizis G., Kolibianakis E.

Poster presentation: 35^th Annual Meeting of ESHRE, Vienna, Austria, 23-26 June 2019

A randomized controlled trial comparing the number of mature oocytes following automated-3D versus manual-2D ultrasound follicle assessment, in high-risk for OHSS patients triggered with GnRH-agonist.

Lainas G., Lainas T., Sfontouris I., Kyriaki S., Zorzovilis I.,Bosdou J.,Grimbizis G.,  Chatzimeletiou A.,  Venetis C., Kolibianakis E.

Poster presentation: 35^th Annual Meeting of ESHRE, Vienna, Austria, 23-26 June 2019

GnRH antagonist administration in the luteal phase for the prevention and management of severe OHSS: A systematic review and meta-analysis.
Lainas T.G., Lainas G., Sfontouris I., Prodromidou A., Venetis C., Zorzovilis I.,Tarlatzis B., Kolibianakis E.
Poster presentation: 34^th Annual Meeting of ESHRE, Barcelona, Spain, 1-4 July 2018

Follicular flushing is associated with a significantly higher oocyte recovery rate compared to no flushing: A randomized controlled trial.
Lainas G., Sfontouris I., Lainas T., Makris A., Venetis C., Zorzovilis I., Petsas G., Tarlatzis B, Kolibianakis E.
Poster presentation: 34^th Annual Meeting of ESHRE, Barcelona, Spain, 1-4 July 2018

[GnRH antagonist administration in the luteal phase for the prevention and management of severe OHSS: A systematic review and meta-analysis.] In Greek
Lainas G., Prodromidou A., Lainas T., Sfontouris I., Makris A., Petsas G., Tarlatzis B., Kolibianakis E.
Oral presentation : 14^th Panhellenic congress of Obstretics and Gynecology. Athens, Greece, 31 May - 3 June 2018

[Effect of the number of embryos transferred on ongoing pregnancy rates in women ≥40 years old undergoing IVF with at least four 2pn oocytes available] In Greek
Lainas G., Makris A., Lainas T., Sfontouris I., Zorzovilis I., Tarlatzis B., Kolibianakis E.
Oral presentation : 14^th Panhellenic congress of Obstretics and Gynecology. Athens, Greece, 31 May - 3 June 2018

Ultrasound and haematological early-luteal-phase predictors of severe ovarian hyperstimulation syndrome (OHSS) in high-risk patients following triggering of final oocyte maturation with human chorionic gonadotrophin (HCG).

Sfontouris I., Lainas G., Lainas T, Venetis C., Makris A., Tarlatzis B, Kolibianakis E..
Poster presentation: 14^th ISUOG International Symposium, Athens, Greece, 20-22 April 2018.

Administration of FSH 8 hours post-triggering of final oocyte maturation with hCG does not improve oocyte maturation rate in normal responders undergoing ICSI.
Sfontouris I., Lainas G., Lainas T., Venetis C., Petsas G., Zorzovilis I., Tarlatzis B., Kolibianakis E.
Poster presentation: 33^rd Annual Meeting of ESHRE, Geneva, Switzerland, 2-5 July 2017.

Recombinant vs. urinary human chorionic gonadotrophin (hCG) for triggering final oocyte maturation in patients at risk for ovarian hyperstimulation syndrome OHSS: a randomized clinical trial.
Lainas G., Lainas T., Venetis C., Sfontouris I., Zorzovilis I., Petsas G., Bosdou J., Tarlatzis B., Kolibianakis E.
Poster presentation: 32^nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

Embryo development after continuous culture in two commercial single-step media: a prospective randomized study with sibling oocytes.
Sfontouris IA, Kolibianakis EM, Lainas GT, Banti M, Venetis C, Petsas GK, Zorzovilis IZ, Lainas TG.
Poster presentation: 32^nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

Elevated progesterone on the day of triggering final oocyte maturation significantly predicts its reoccurrence in a subsequent IVF cycle.
Venetis C., Kolibianakis E., Bosdou J., Lainas G., Sfontouris I., Tarlatzis B., Lainas T.
Oral presentation: 32^nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

GnRH agonist for triggering final oocyte maturation in patients with PCO at high risk for severe OHSS: factors predicting live birth in subsequent FRET cycles.
Tarlatzi T., Bosdou J., Venetis C., Lainas G., Sfontouris I., Makedos A., Chatzimeletiou K., Zepiridis L., Mitsoli A., Savaidou D., Lainas T., Tarlatzis B., Kolibianakis E.
Oral presentation: 32^nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

Similar implantation and pregnancy rates using a single medium versus sequential media for embryo culture: a randomized controlled trial.
Sfontouris IA, Kolibianakis EM, Lainas GT, Zorzovilis IZ, Petsas GK, Lainas TG
Poster presentation: 31^st Annual Meeting of ESHRE, Lisbon, Portugal, 14-17 June 2015

The optimal dose of triptorelin for triggering final oocyte maturation in patients at high-risk for OHSS: a randomized clinical trial.
Lainas G.T., Bosdou J.K., Venetis C.A., Sfontouris I.A., Chatzimeletiou K., Zepiridis L., Makedos A., Daniilidis A., Mitsoli A., Savvaidou D., Lainas T.G., Tarlatzis B.C., Kolibianakis E.M.
Oral presentation: 31^st Annual Meeting of ESHRE, Lisbon, Portugal, 14-17 June 2015

Blastocyst development in single-step versus sequential culture media: a prospective randomized study with sibling oocytes.
Sfontouris IA, Kolibianakis EM, Lainas GT, Zorzovilis IZ, Petsas GK, Lainas TG.
Oral presentation: 30^th Annual Meeting of ESHRE, Munich, Germany, 29 June – 2 July 2014

Are pregnancy outcomes affected by the presence of hysteroscopic findings in asymptomatic women undergoing in vitro fertilization treatment?
Lainas, GT; Navaratnarajah, R; Sfontouris, IA; Venetis, C; Zorzovilis, IZ; Lainas TG
Oral presentation: 23^rd Annual Meeting of ESGE, Brussels, 24-26 September 2014

Basal progesterone levels represent the only independent risk factor prior to initiation of stimulation for elevated progesterone on the day of hCG.
Venetis CA, Kolibianakis EM, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Poster Presentation: 70^th Annual Meeting of ASRM, Hawaii, USA, 18-22 October 2014.

The true impact of elevated progesterone on the day of hCG on pregnancy rates after IVF: a cohort analysis of more than 3,600 cycles.
Venetis CA, Kolibianakis EM, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Poster Presentation: 70^th Annual Meeting of ASRM, Hawaii USA, 18-22 October 2014.

Triggering of final oocyte maturation with gonadotrophin releasing hormone agonist in patients with polycystic ovaries undergoing in vitro fertilization.
Tarlatzi TB, Kolibianakis EM, Bosdou JK, Venetis CA, Makedos A, Chatzimeletiou K, Zepiridis L, Lainas G, Sfontouris IA, Lainas T, Tarlatzis BC.
Poster Presentation: 70^th Annual Meeting of ASRM, Hawaii USA, 18-22 October 2014.

Effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on pregnancy rates in patients with multiple unsuccessful IVF attempts.
Sfontouris IA, Lainas GT, Anagnostara K, Kolibianakis EM, Lainas TG.
Oral presentation: 29^th Annual Meeting of ESHRE, London, UK 7-10 July 2013.

Triggering of final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF.
Makedos A., Kolibianakis EM., Venetis C.A, Masouridou S., Chatzimeletiou K., Zepiridis L., Mitsoli A., Lainas G., Sfontouris I., Tzamtzoglou A., Kyrou D., Lainas T. Tarlatzis BC.
Poster presentation: 29^th Annual Meeting of ESHRE, London, UK 7-10 July 2013

Triggering final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF.
Kolibianakis EM, Kyrou D, Venetis CA, Sfontouris I.A., Lainas T.G., Tarlatzis B.C.
Poster presentation: 68^th Annual Meeting of ASRM, San Diego, California, 20-24 October 2012

[Triggering final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF.] In Greek
Masouridou S, Kolibianakis E, Kyrou D, Sfontouris I, Venetis C, Lainas G,Zepeiridis L, Bili E, Gribizis G, Mitsoli A, Sanopoulou T, Pagkou T, Lainas T, Tarlatzis B
Oral presentation: 12^th Panhellenic congress of Obstretics and Gynecology. Thessaloniki, Greece, 17 - 20 May 2012

Assessment of embryo selection using non-invasive metabolomic analysis as an adjunct to morphology indicates improvement in implantation and fetal cardiac activity rates.
Sfontouris I.A.,Lainas G.T., Sakkas D., Iliadis G.S., Anagnostara K., Zorzovilis I.Z., Petsas G.K., Lainas T.G.
Oral presentation: 27^th Annual Meeting of ESHRE, Stockholm,Sweden,3-6 July 2011
Nominated for the "Fertility Society of Australia Exchange Award"

Treatment of peritoneal and ovarian endometriosis by using CO2 laser with or without 'swiftlase'.
Lainas T., Petsas G., Stathopoulos I., Bournas N.,Eliadis S.
4th Congress of the European Society for Gynaecological Endoscopy
Brussels, Belgium,6 - 9 December 1995.

Microsurgery in the treatment of tuboperitoneal infertility.
Sarris S., Lainas T., Alexandrakis G., Eliadis S., Comninos A.
III World Congress of Reproduction, Berlin 22-23 March 1981.

Tubercolosis of the female genital system.
Comninos A., Tsamanis E., Lainas T., Al-Achmant M., Sarris S.
XI World Congress on Fertility and Sterility Dublin, Ireland, 26 June-1 July 1983

Treatment of pelvic pain by ablation of the uterine nerve using Laser-Laparoscopic surgery (L.U.N.A.).
Lainas T., Petsas G., Zorzovilis I., Stathopoulos I., Iliadis S.
Hellenic Medical Congress, Athens, 5-9 May 1998

L.U.N.A.(Laser uterine nerve ablation) for the treatment of severe dysmenorrhea - dyspareunia.
Lainas, I. Zorzovilis, I. Gatos, G. Petsas, S. Iliadis, K. Bouzouni and A. Ioakimidis
7th Panhellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete, 14-17 May 1997

Rectovaginal septum endometriosis. Diagnosis and treatment.
Lainas, S. Iliadis, I. Zorzovilis, I. Gatos, I. Stathopoulos, G. Petsas, N. Bournas
7th Panhellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete, 14-17 May 1997

Bicornis-bicervical uterus with or without haematocolpos.
Lainas, I. Zorzovilis, V. Paschoudis, I. Stathopoulos, K. Kostaras, S. Iliadis
7th Panhellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete 14-17 May 1997

Treatment of peritoneal and ovarian endometriosis using Swiftlase.
Lainas T., Zorzovilis I., Petsas G., Stathopoulos I., Ioakimidis A., Paraschos A., Iliadis S.
7th Panhellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete 14-17 May 1997

Cervical sarcoma in a 15 year old girl diagnosed using hysteroscopy.
Lainas T., Petsas G., Ioakimidis A., Paschoudis V.
2nd Hellenic Congress of Child-Adolescent Gynaecology and Endocrinology, Athens, 6-9 December 1995

Pelvic infection disease and perihepatitis.
Lainas T., Iliadis S., Petsas G., Ioakimidis A., Stathopoulos A., Paschoudis V.
2nd Hellenic Congress of Infection, Athens, 28-29 January 1995

Two years experience of a laparoscopic surgery unit at Athens Maternity hospital (video).
Lainas T., Iliadis S., Petsas G., Ioakimidis A., Stathopoulos A., Paschoudis V.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Laparoscopic management of ovarian cysts performed with the method of double suction using Nezhat probe without content spilage.
Lainas T., Iliadis S., Petsas G., Ioakimidis A., Stathopoulos A., Paschoudis V.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Hysteroscopic diagnosis and treatment of endometrial cavity pathology.
Lainas T., Iliadis S., Paschoudis V., Hatzigiannis E., Ioakimidis A., Stathopoulos I., Tzigounis B.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Laparoscopic diagnosis and treatment of subtle lesions of peritoneal endometriosis.
Lainas T., Iliadis S., Paschoudis V., Hatzigiannis E., Ioakimidis A., Stathopoulos I., Tzigounis B.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Curtis-Fitz-Hugh syndrome and chlamydial pelvic infection.
Lainas T., Iliadis S., Paschoudis V., Ioakimidis A.,Stathopoulos I.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Laparoscopic treatment of ectopic pregnancy.
Iliadis S., Lainas T., Hatzigiannis E., Ioakimidis A., Paschoudis V.,Stathopoulos I.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Laparoscopic treatment of peritoneal and ovarian endometriosis using Laser CO2.
Lainas T., Iliadis S., Paschoudis V., Ioakimidis A.,Stathopoulos I.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Referral frequency for obstetric ultrasound, pregnancy DOPPLER and biophysical profile.
Stathopoulos I., Tzeferakos A., Christopoulos I., Lainas T.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Delay of labour initiation and biophysical profile.
Stathopoulos I., Iliadis S., Lainas T., Paschoudis V.,Gogas K.
6th Hellenic Congress of Obstetrics and Gynaecology, Athens, 23-26 November 1994

Diagnosis of vaginal adenosis using the microhysteroscope Hamou II.
Lainas T., Iliadis S., Ioakimidis A.,Paschoudis V., Stathopoulos I.
1st Hellenic Congress of Child-Adolescent Gynaecology and Endocrinology, Kastri, Athens, 8-11 December 1993

Tuberculosis of the female reproductive system.
Komninos A., Tsamanis E., Lainas T., Al-Ahmar M., Sarris S.
Joint Meeting of the Greek Society of Fertility and Sterility and British Fertility Society, Rhodes, 29-30 April 1983

Microsurgical treatment of tuboperitoneal infertility.
Sarris S., Verikios N., Lainas T., Komninos A.
2nd Hellenic Congress of Perinatal Medicine, Athens, 24-25 October 1981

Haematological changes during normal gestation.
Mavrelos K., Lainas T., Primikiris D., Antonopoulos M., Komninos A.
2nd Hellenic Congress of Perinatal Medicine, Athens, 24-25 October 1981

The value of laparoscopy in the investigation of female infertility.
Sarris S., Komninos A., Lainas T., Iliadis S.
7th Hellenic Medical Congress, Athens, 7-10 May 1981

Microsurgical treatment of female infertility.
Sarris S., Komninos A., Lainas T., Iliadis S.
6th Hellenic Medical Congress, Athens, 8-11 May 1980

Laparoscopic investigation of 270 cases of female infertility.
Komninos A., Sarris S., Lainas T.
6th Hellenic Medical Congress, Athens 8-11 May 1980

Eugonia is a licensed Assisted Reproduction Unit and Cryopreservation Bank by Greek National Authority of Assisted Reproduction , fulfilling all the requirements that are defined by the Greek legislation.

We have over 30 years of experience and produce important scientific work, which contributes to the international scientific developments. We also have modern technical equipment and our success rates are among the highest internationally. See more

The selection of an ART Unit is a very important decision, and it is your decision. The selection criteria can be objective or subjective. They are related to the efficiency and the specifications of the Unit, but also the personal relation of trust that develop with its staff.

We offer you all the information you need and all the reasons to choose Eugonia:

• Our pregnancy rates are among the highest internationally
• We achieve a successful pregnancy in the first IVF attempt for the majority of women
• We offer a solution to previous failed IVF attempts
• We formulate an individualized and friendly treatment for each couple.

Eugonia…with international recognition

•  We contribute to the international scientific developments, with our research activity and by publishing original studies in high-impact scientific journals.
• We have deep knowledge and experience due to continuous scientific update and the principles of evidence-based medicine.
• We design optimal protocols of ovarian stimulation for women with poor response and women with polycystic ovaries
• We treat severe OHSS safely and efficiently.

Eugonia…with knowledge, high specifications and technology

•  We have:
  a)    Quality management certification EN 15224:2016
  b)    Modern technical equipment
  c)    A detailed and extensive database, which supplies us with statistical figures, useful in everyday practice but also for the publication of original studies
• We reduce the physical burden by using new patient-friendly protocols with a short duration (antagonists, single injection, natural cycle, mild stimulation protocols)
• We preserve female reproductive potential by oocyte cryopreservation (vitrification)
• We avoid the transmittance of hereditary genetic diseases by preimplantation genetic diagnosis/screening (PGD/PGS).

Eugonia…with responsibility and sensitivity

•  We ensure that the couples are fully informed about each phase of the treatment, with the option of professional psychological support.
• We adhere to strict principles of morale and bioethics.

Our best assets

• Knowledge

A deep understanding of Reproductive Medicine and Endocrinology is not self- evident, but it is obtained through a continuous effort for scientific awareness and improvement, something that is reflected in the success rates of every Unit. At Eugonia, we are proud of our Unit’s international recognition thanks to our high pregnancy rates and our continuous presence in scientific developments of Reproductive Medicine at an international scale through our unique scientific work and our participation in international Institutions.

• Scientific work

Our team, coordinated by Dr.T.Lainas, already numbers a long series of scientific articles in esteemed scientific journals specialized in Human Reproduction and IVF. These articles, reflect our deep knowledge of the scientific field, the best scientific and technological training of our team and the constant effort by all the members of Eugonia (physicians, midwifes, embryologists) self-improvement regarding the quality of the services we provide to our patients.

• We tell the truth

All our patients can trust us, because we treat them with honesty and dignity regarding their success rates and their treatment. It is our highest principle, that all couples have the right to detailed and honest information. We work in a trustworthy environment, with direct one-to-one communication with each couple, in order to reduce psychological stress.

• Our laboratory and medical team

We have the most up-to-date technologies and techniques and an ideal medical team, so we can guarantee clinical and scientific excellence combined with high pregnancy rates.

• Participation in European Organisations

Dr. G. Lainas holds the position of Coordinator-Elect of the Special Interest Group for “Reproductive Endocrinology” of ESHRE. This is a unique post of global exposure offered to internationally acclaimed scientists and clinicians, who steer the developments of Reproductive Medicine at an international scale.

Eugonia - Pioneer in EN 15224 certification

Eugonia is one of only a handful of IVF units that has obtained the new Standard EN 15224:2016 certification

This European certification, aims at upgrading our quality systems, our patient's safety and the effectiveness of our treatments. This specific certification procedure was especially demanding, with the presence of five inspectors.

"EN 15224:2012" concerns, among other things, the study, assessment and management of any clinical or non-clinical risk factor that may lead to a negative impact, and will soon become mandatory for all ART Units in the country, due to the recent law.

This certification is also a good international credential for medical tourism because it certifies medical services of a high standard. This development confirms the commitment of the Specialists of Eugonia to provide the most advanced services to the couples, from all over the world, which trust us in order to become parents.

Eugonia- ISO 9001 certification

Eugonia was one of the first ART Units to be certified for it’s services in Assisted Reproductive Medicine.

The ISO certification 9001:2008 was been obtained after a detailed review/inspection of the Quality System in our unit in January 2010. This ISO illustrates our constant quality control in all levels of Eugonia’s departments (clinical, laboratory, administrative) leading to higher success rates and patient satisfaction.

We focus on the provision of services of high scientific level through the operation of a high quality Assisted Reproduction Technology Unit.

We rely on:

• Our highly qualified scientists and our specialized and experienced nursing staff.
• Modern laboratory setup according to the strictest international models.
• Individualized treatment and care for each infertile couple.
• Scientific connections of our Unit with research centers and Universities in Greece and abroad.
• Continuous clinical study and research, and the constant participation of our team in Greek and international scientific conferences and seminars.

We ensure that:

• The environment of trust and the warm, personal communication of our team with the couple drastically reduce any psychological burden.
• The expected successful outcome of your attempt is feasible with the minimal psychological, physical and financial cost.

Eugonia- the evolution of “Iatriki Erevna”- operates for 30 years and has achieved significantly high pregnancy rates, putting it amongst the top performing clinics internationally.

Our scientific team coordinated by  Dr.T.lainas has published  several reports/studies in scientific magazines or congresses.

• Pioneer scientific work
• Scientific papers published in international scientific journals - The importance of publications
• Abstracts presented in international and national conferences

Pioneer scientific work

Our team coordinated by  Dr.T.Lainas already numbers a long series of  scientific articles in esteemed scientific journals specialized in Human Reproduction and In Vitro fertilization.

Particularly, we have published the largest study, that has ever been undertaken in the international literature regarding women with poor ovarian response (poor responders). The number of women included in this study is by far the greatest in comparison with other relevant published issues. It shows that the use of the new pharmaceutical protocol has statistically higher success rates and has been published in Human Reproduction journal(official journal of European Society for Human Reproduction and Embryology - ESHRE).

In addition, in a more recent study of our Unit, which is the largest worldwide with regard to the number of patients with polycystic ovarian syndrome, we show that the use of the flexible protocol of GnRH antagonist results in an approximately 20% reduction of the PCOS, when compared to the protocol,  without reducing  of pregnancy rates.

Furthermore, we achieved a safe and effective management of the established severe ovarian hyperstimulation syndrome, along with the first births of healthy babies. Our study about the management of severe OHSS was described as an original idea by the scientific journal reviewers. The safety and effectiveness of this method challenges the current dogma that the only safe OHSS prevention method is cycle cancellation, which of course has many psychological and economical implications.

At last, in a recent study, we have shown that the Natural Cycle protocol leads to higher birth rates that the common protocols in women with poor ovarian response.

At Eugonia, we strongly believe that only through research and constant development we progress and increase our clinical pregnancy rates following assisted reproduction treatment.

The embryology laboratory is where the collection and fertilization of the oocytes takes place and where the embryos remain under culture conditions until the day of embryo transfer. It is a place of high specialization and sterility, with advanced equipment, that under the guidance of an experienced and well-trained embryologist have a crucial effect on the pregnancy rates of a Unit. 

The ideal embryology laboratory, as the one in Eugonia Unit, is characterized by:

• Medical Staff. Highly trained embryologists, that are up to date with the latest scientific advances in the field of assisted reproduction.
  
  Meet our embryologists:
  
  

  Embryologists

  • Marianna Xenariou MSc

    Clinical Embryologist

  • Nikos Mpillias

    Clinical Embryologist MSc

  • Irini Spiratou MSc

    Clinical Embryologist

  • Rodopi Papachristopoulou

    Biologist Embryologist

  » Show all
  
  
  
• Laboratory and equipment. The design of the embryology laboratory is based on the philosophy of a “Clean Room”, regarding the materials, the surfaces and the equipment. Thus, the VOCs (Volatile organic compounds) are reduced to a minimum.  Cleanliness of the environment is achieved with the use of special filters and air-exchange systems.
  
  The equipment of our laboratory is state if the art, ensuring precise and effective handling and optimal culture conditions for the embryos.  The embryology lab is, among others, equipped with the Integra 3 Micromanipulator System and the Octax system, which enables the 24/7 monitoring of all the critical parameters of the laboratory (temperature and pH within the incubators, temperature of embryo storage tanks and storage fridges, CO2 and N2 canister levels etc).
  
  
  
  These new systems represent an important investment by the Unit for the improvement of the quality and safety of our services, through the improvement of all important laboratory parameters, upon which hinges the successful outcome of an IVF attempt.

• Quality assurance. The embryos and gametes are handled with care, taking into account each  patient’ s circumstances. Our laboratory follows clear and detailed protocols for every procedure, including strict double-witnessing of every sample and every clinical process, in order to ensure the upmost safety and transparency towards our patients. Finally, our embryologists maintain a database with detailed clinical information. 
  
  
  
  
• Research work that leads to publications in internationally renowned scientific journals. Through research and continuous awareness, we can offer valid and effective treatment, with high success rates. This philosophy has been recognized internationally by the European Society of Human Reproduction and Embryology (ESHRE), which has elected our chief embryologist, Ioannis Sfontouris, as coordinator of the Special Interest Group for Embryology.
  
  
• External quality control and ISO accreditation from an official government authority
  
  

 All the above characterise the embryology laboratory at Eugonia and reflect the high pregnancy rates in our Unit.

In our establishments operate daily:

• Diagnostic units: ultrasound, Doppler, hormone, blood, microbiology and biochemistry laboratories.
• Office Hysteroscopy.
• Cryopreservation of oocytes, embryos and sperm.
• Fully equipped state-of-the-art Embryology Laboratory.
• Theatre for oocyte retrievals and embryo transfers.
• Three 2-bed recovery rooms.
• Sperm collection room.

The areas of the Embryology Laboratory and of egg collections/embryo transfers operate under special systems for sterile controlled atmosphere. In all clinical and laboratory procedures, non-toxic single-use materials are used, chosen for their high quality and effectiveness.

Our Unit was designed to offer a functional, as well as comfortable and pleasant environment.

«The state-of-the-art technology infrastructure utilizes to the full the capabilities of the scientific staff».