Fertility - Infertility

How does endometriosis affect fertility

Proposed mechanisms through which endometriosis may affects women's fertility are the following:

  • Mechanically, via adhesions, immotile ovaries, tubal blockage etc.
  • Ovulation disorders such as anovulation, poor luteal phase and/or luteinized unruptured follicle syndrome.
  • Dysfunctional fallopian tubes due to toxic factor caused by the condition, such as prostagladins.
  • Reduced implantation potential of the embryo due to integrins and other embryotoxic factors produced by the condition.
  • Modified immune response due to high T, B and NK counts.
  • Pelvic inflammation which can lead to high levels of IL1, TNF and prostaglandins.

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