GIFT / ZIFT methods


GIFT (Gamete IntraFαllopian Transfer) is an assisted reproductive procedure which involves placing in the fallopian tube, 3-4 oocytes mixed with sperm, using a special catheter. Sperm used in GIFT is activated using the Percoll method,which includes separating an adequate number of motile, morphologically normal spermatozoa from the initial sample.
Before egg retrieval a woman’s ovaries are stimulated, according to medical protocols that promote multiple follicular growth. Egg retrieval is usually performed transvaginally and rarely laparoscopically. On the same day, laparoscopy is used to transfer the gametes (oocytes and sperm) in the fallopian tube. It is obvious that, GIFT requires general anesthesia and hospital admission.
Tubal patency (at least one tube) and normal sperm are prerequisites for GIFT.
GIFT is commonly chosen in cases of unexplained infertility, mild endometriosis, mild oligo-asthenozoospermia and previous failed Intrauterine Inseminations (IUI). Indications that are present in the majority of cases requiring infertility treatment.
GIFT disadvantages include, high incidence of ectopic pregnancy, laparoscopic surgery under general anesthesia, lower pregnancy rates compared to IVF and inability to check fertilization rates. In our days, GIFT is rarely the preferred choice of treatment.


ZIFT (Zygote IntraFllopian Transfer) ) is an assisted reproductive procedure which involves placing laparoscopically in the fallopian tube, the fertilized eggs – at this stage called the zygotes-, using a special catheter. Zygotes are produced after mixing the oocytes with motile sperm in the laboratory.
Embryos are transferred in the fallopian tube, instead of the uterus, 24 – 48 hours after egg collection. In our days, ΖIFT is not a method of choice.