Innovative scientific work

Our scientific team coordinated by  Dr.T.lainas has published  several reports/studies in scientific magazines or congresses.

Pioneer scientific work

Our team coordinated by  Dr.T.Lainas already numbers a long series of  scientific articles in esteemed scientific journals specialized in Human Reproduction and In Vitro fertilization.

Particularly, we have published the largest study,  that has ever been undertaken in the international literature regarding women with poor ovarian response (poor responders). The number of women included in this study is by far the greatest in comparison with other relevant published issues. It shows that the use of the new pharmaceutical protocol protocol has statistically higher success rates  and has been published in Human Reproduction journal(official journal of European Society for Human Reproduction and Embryology - ESHRE).

In addition, in a more recent study of our center, which is the largest worldwide with regard to the number of patients with polycystic ovarian syndrome, we show that the use of the flexible protocol of GnRH antagonist results in an approximately 20% reduction of the PCOS, when compared to the protocol,  without reducing  of pregnancy rates.

Furthermore, we achieved a safe and effective management of the established severe ovarian hyperstimulation syndrome, along with the first births of healthy babies. Our study about the management of severe OHSS was described as an original idea by the scientific journal reviewers. The safety and effectiveness of this method challenges the current dogma that the only safe OHSS prevention method is cycle cancellation, which of course has many psychological and economical implications.

At Eugonia, we strongly believe that only through research constant development we progress and increase our clinical pregnancy rates following assisted reproduction treatment.


Scientific papers published in peer – review journals

Basal serum progesterone and history of elevated progesterone on the day of hCG are significant predictors of late follicular progesterone elevation in GnRH antagonist IVF cycles.

Venetis CA, Kolibianakis EM, Bosdou JK, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Human Reproduction, 2016. In press.
See the publication
 
Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles.
Venetis CA, Kolibianakis EM, Bosdou JK, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG.
Hum Reprod 2015;30:684-91.
See the publication
 
Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved.
Sfontouris IA, Kolibianakis EM, Lainas GT, Navaratnarajah R, Tarlatzis BC, Lainas TG.
J Assist Reprod Genet 2015;32:691-7.
See the publication
 
Live birth rates after modified natural cycle compared with high-dose FSH stimulation using GnRH antagonists in poor responders.
Lainas TG, Sfontouris IA, Venetis CA, Lainas GT, Zorzovilis IZ, Tarlatzis BC, Kolibianakis EM.
Human Reproduction 2015;30:2321-30.
See the publication
 
No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individual patient data meta-analysis.
Vergouw CG, Heymans MW, Hardarson T, Sfontouris IA, Economou KA, Ahlström A et al.
Human Reproduction 2014;29:455-61. See the publication

Serum vascular endothelial growth factor levels following luteal gonadotrophin-releasing hormone antagonist administration in women with severe early ovarian hyperstimulation syndrome,
GT Lainas, EM Kolibianakis, IA Sfontouris, IZ Zorzovilis, GK Petsas, TG Lainas, BC Tarlatzis. BJOG: An international Journal of Obstetrics and Gynaecology, Feb 2014 . See the publication
 
Non-invasive metabolomic analysis using a commercial NIR instrument for embryo selection,
Sfontouris I. A., Lainas G. T., Sakkas D., Zorzovilis I. Z., Petsas G. K., and Lainas T. G.. Journal of Human Reproductive Sciences 2013; 6: 133-139. See the publication

Pregnancy and neonatal outcomes following luteal GnRH antagonist administration in patients with severe early OHSS,
Lainas G. T., Kolibianakis E. M., Sfontouris I. A., Zorzovilis I. Z., Petsas G. K., Lainas T. G., and Tarlatzis B. C. Human Reproduction 2013; 28: 1929-1942. See the publication

Outpatient management of severe early OHSS by administration of GnRH antagonist in the luteal phase: an observational cohort study,
Lainas G., Kolibianakis E., Sfontouris I., Zorzovilis I., Petsas G., Tarlatzi T., Tarlatzis B., and Lainas T.. Reproductive Biology and Endocrinology 2012; 10: 69.See the publication

Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective RCT.
Trifon G Lainas, Ioannis A Sfontouris, Ioannis Z Zorzovilis, George K Petsas, George T Lainas, Efthymia Alexopoulou, Efstratios M Kolibianakis Human Reproduction, 2010, Vol 25, No 3, pp. 683-689 See the publication

Live births after management of severe OHSS by GnRH antagonist administration in the luteal phase
TG Lainas, IA Sfontouris, IZ Zorzovilis, GK Petsas, GT Lainas, E Alexopoulou, EM Kolibianakis Reproductive BioMedicine Online, 2009, Vol 19, No 6, pp 789-795 See the publication
 
Management of severe OHSS using GnRH antagonist and blastocyst cryopreservation in PCOS patients treated with long protocol
TG Lainas, IA Sfontouris, IZ Zorzovilis, GK Petsas, GT Lainas, GS Iliadis, EM Kolibianakis. Reproductive BioMedicine Online, 2009, Vol. 18, No 1, pp 15-20 See the publication
 
Flexible GnRH antagonist versus flare-up GnRH agonist protocol in poor responders treated by IVF: a randomized controlled trial
Trifon G. Lainas, Ioannis A. Sfontouris, Evangelos G. Papanikolaou, John Z. Zorzovilis, George K. Petsas, George T. Lainas and Efstratios M. Kolibianakis. Human Reproduction, 2008, Vol. 23, No 6, pp. 1355-1358 See the publication
 
Managment of severe early ovarian hyperstimulation syndrome by re-initiation of GnRH antagonist
TG Lainas, IA Sfontouris, IZ Zorzovilis, GK Petsas, GT Lainas, EM Kolibianakis Reproductive BioMedicine Online, 2007, Vol. 15, No 4, pp 408-412 See the publication
 
Initiation of GnRH antagonist on Day 1 of stimulation as compared to the long agonist protocol in PCOS patients. A randomized controlled trial: effect on hormonal levels and follicular development.
Lainas TG, Petsas GK, Zorzovilis IZ, Iliadis GS, Lainas GT, Cazlaris HE, Kolibianakis EM Human Reproduction, 2007, Vol. 22, No 6, pp. 1540-1546 See the publication
 
In a flexible antagonist protocol, earlier, criteria-based initiation of GnRH antagonist is associated with increased pregnancy rates in IVF.
Trifon Lainas, John Zorzovilis, George Petsas, Georgia Stavropoulou, Haris Cazlaris, Vassiliki Daskalaki, George Lainas and Efthymia Alexopoulou Human Reproduction, 2005, Vol. 20, No 9, pp. 2426-2433 See the publication
 
Osseous metaplasia: case report and review.
Trifon Lainas M.D., Ph.D., Ioannis Zorzovilis M.D., Georgios Petsas M.D., Ph.D., Efthymia Alexopoulou M.D., George Lainas and Tasos Ioakimidis, M.D Fertility and Sterility, 2004, Vol. 82, No 5, pp. 1433-1435 See the publication
 
Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization
Trifon Lainas M.D., Georgios Petsas M.D., Georgia Stavropoulou B.Sc., Efthymia Alexopoulou M.D., George Iliadis M.Sc., Dimitrios Minaretzis M.D. Fertility and Sterility, 2002, Vol. 78, No 3, pp. 529-533 See the publication

Abstracts presented in international and national conferences

 

Embryo development after continuous culture in two commercial single-step media: a prospective randomized study with sibling oocytes
Sfontouris IA, Kolibianakis EM, Lainas GT, Banti M, Venetis C, Petsas GK, Zorzovilis IZ, Lainas TG (2016). Poster presentation: 32nd  Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

 

Recombinant vs. urinary human chorionic gonadotrophin (hCG) for triggering final oocyte maturation in patients at risk for ovarian hyperstimulation syndrome OHSS: a randomized clinical trial
Lainas, T. Lainas, C. Venetis, I. Sfontouris, I. Zorzovilis, G. Petsas, J. Bosdou, B. Tarlatzis, E. Kolibianakis (2016) Poster presentation: 32nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

 

Elevated progesterone on the day of triggering final oocyte maturation significantly predicts its reoccurrence in a subsequent IVF cycle
Venetis, E. Kolibianakis, J. Bosdou, G. Lainas, I. Sfontouris, B. Tarlatzis, T. Lainas (2016) Oral presentation: 32nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

 

GnRH agonist for triggering final oocyte maturation in patients with PCO at high risk for severe OHSS: factors predicting live birth in subsequent FRET cycles
Tarlatzi, J. Bosdou, C. Venetis, G. Lainas, I. Sfontouris, A. Makedos, K. Chatzimeletiou, L. Zepiridis, A. Mitsoli, D. Savaidou, T. Lainas, B. Tarlatzis, E. Kolibianakis. (2016) Oral presentation: 32nd Annual Meeting of ESHRE, Helsinki, Finland, 3-6 July 2016

 

Similar implantation and pregnancy rates using a single medium versus sequential media for embryo culture: a randomized controlled trial
Sfontouris IA, Kolibianakis EM, Lainas GT, Zorzovilis IZ, Petsas GK, Lainas TG (2015), Human Reproduction 30 (Suppl 1):i232. Poster presentation: 31st Annual Meeting of ESHRE, Lisbon, Portugal, 14-17 June 2015

 

The optimal dose of triptorelin for triggering final oocyte maturation in patients at high-risk for OHSS: a randomized clinical trial.
G.T. Lainas, J.K. Bosdou, C.A. Venetis, I.A. Sfontouris, K. Chatzimeletiou, L. Zepiridis, A. Makedos, A. Daniilidis, A. Mitsoli, D. Savvaidou, T.G. Lainas, B.C. Tarlatzis, E.M. Kolibianakis. (2015 Human Reproduction 30 (Suppl 1):i95. Oral presentation: 31st Annual Meeting of ESHRE, Lisbon, Portugal, 14-17 June 2015

 

Blastocyst development in single-step versus sequential culture media: a prospective randomized study with sibling oocytes.
I.A. Sfontouris, E.M. Kolibianakis, G.T. Lainas, I.Z. Zorzovilis G.K. Petsas, T.G. Lainas (2014) Human Reproduction 29 (suppl 1): i2. Oral presentation: 30th Annual Meeting of ESHRE, Munich, Germany, 29 June – 2 July 2014

 

Are pregnancy outcomes affected by the presence of hysteroscopic findings in asymptomatic women undergoing in vitro fertilization treatment?
Lainas, GT; Navaratnarajah, R; Sfontouris, IA; Venetis, C; Zorzovilis, IZ; Lainas TG (2014) Gynecological Surgery, 11 (Supl.1): ES23-0227; Oral presentation, ESGE Annual Meeting, Brussels 24-27 September 2014

 

Basal progesterone levels represent the only independent risk factor prior to initiation of stimulation for elevated progesterone on the day of hCG.
CA Venetis, EM Kolibianakis, GT Lainas, IA Sfontouris, BC Tarlatzis, TG Lainas. (2014) Fertility and Sterility 102 (3), e253. Poster: ASRM Annual Meeting, Hawaii USA, 18-22 October 2014

 

The true impact of elevated progesterone on the day of hCG on pregnancy rates after IVF: a cohort analysis of more than 3,600 cycles.
CA Venetis, EM Kolibianakis, GT Lainas, IA Sfontouris, BC Tarlatzis, TG Lainas Fertility and Sterility 102 (3), e318. Poster: ASRM Annual Meeting, Hawaii USA, 18-22 October 2014

 

Triggering of final oocyte maturation with gonadotrophin releasing hormone agonist in patients with polycystic ovaries undergoing in vitro fertilization.
TB Tarlatzi, EM Kolibianakis, JK Bosdou, CA Venetis, A Makedos, K Chatzimeletiou, L Zepiridis, G Lainas, IA Sfontouris, T Lainas, BC Tarlatzis Fertility and Sterility 102 (3), e262-e263. Poster: ASRM Annual Meeting, Hawaii USA, 18-22 October 2014

 

Effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on pregnancy rates in patients with multiple unsuccessful IVF attempts.
Sfontouris I. A., Lainas G. T., Anagnostara K., Kolibianakis E. M., and Lainas T. G. Human Reproduction 2013; 28: i60-i62. Ομιλία, ESHRE 29th Annual Meeting, Λονδίνο, 7-10 Ιουλίου 2013

 

Triggering of final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF
Sfontouris I. A., Lainas G. T., Sakkas D., Iliadis G. S., Anagnostara K., Zorzovilis I. Z., Petsas G. K., and Lainas T. G. Human Reproduction 2011; 26: i86. ESHRE 29th Annual Meeting, Λονδίνο, 7-10 Ιουλίου 2013

 

Triggering final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF
Kolibianakis E. M., Kyrou D., Venetis C. A., Sfontouris I., Lainas T. G., and Tarlatzis B. C.. Fertil. Steril. 2012; 98: S259. ASRM 68th Annual Meeting, 20 - 24 October 2012

 

Triggering final oocyte maturation with GnRH agonist in patients with polycystic ovaries undergoing IVF
Masouridou S., Kolibianakis E. M., Kyrou D., Sfontouris I., Venetis C. A., Lainas G.T., Zepiridis L., Mpili E., Grimpizis G., Mitsoli A., Sanopoulou Th., Pagou Th., Lainas T.G., Tarlatzis B. C. 12th Hellenic Congress of Obstetrics and Gynaecology, Thessaloniki , 17-20 May 2012.

 

Assessment of embryo selection using non-invasive metabolomic analysis as an adjunct to morphology indicates improvement in implantation and fetal cardiac activity rates
Sfontouris I. A., Lainas G. T., Sakkas D., Iliadis G. S., Anagnostara K., Zorzovilis I. Z., Petsas G. K., and Lainas T. G. Human Reproduction 2011; 26: i86.
Oral presentation, ESHRE Conference 2011, Stockholm, Sweden
3-6 July 2011
Nominated for the "Fertility Society of Australia Exchange Award"

 

Treatment of peritoneal and ovarian endometriosis by using CO2 laser with or without 'swiftlase'.
T. Lainas, G. Petsas, I. Stathopoulos, N. Bournas, S. Eliadis.
4th Congress of the European Society for Gynaecological Endoscopy
Brussels, Belgium,
6 - 9 Dec. 1995.

 

Microsurgery in the treatment of tuboperitoneal infertility.
S. Sarris, T. Lainas, G. Alexandrakis, S. Eliadis and A. Comninos.
III World Congress of Reproduction, Berlin 22-23 March 1981.

 

Tubercolosis of the female genital system.
A. Comninos, E. Tsamanis, T. Lainas,
M. Al-Achmant and S. Sarris.
XI World Congress on Fertility and Sterility Dublin, IRELAND, 26 June-1 July 1983

 

Treatment of pelvic pain by ablation of the uterine nerve using Laser-Laparoscopic surgery (L.U.N.A.).
T. Lainas, I G. Petsas. Zorzovilis, I. Stathopoulos and S. Iliadis
Hellenic Medical Congress May 1998

 

L.U.N.A.(Laser uterine nerve ablation) for the treatment of severe dysmenorrhea - dyspareunia.
T. Lainas, I. Zorzovilis, I. Gatos, G. Petsas, S. Iliadis, K. Bouzouni and A. Ioakimidis
7th Hellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete May 1997

 

Rectovaginal septum endometriosis. Diagnosis and treatment.
T. Lainas, S. Iliadis, I. Zorzovilis, I. Gatos, I. Stathopoulos, G. Petsas, N. Bournas
7th Hellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete May 1997

 

Bicornis-bicervical uterus with or without haematocolpos.
T. Lainas, I. Zorzovilis, V. Paschoudis, I. Stathopoulos, K. Kostaras, S. Iliadis
7th Hellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete May 1997

 

Treatment of peritoneal and ovarian endometriosis using Swiftlase.
T. Lainas, I. Zorzovilis, G. Petsas, I. Stathopoulos, A. Ioakimidis, A. Paraschos, S. Iliadis
7th Hellenic Congress of Obstetrics and Gynaecology, Iraklio, Crete May 1997

 

Cervical sarcoma in a 15 year old girl diagnosed using hysteroscopy.
T. Lainas, G. Petsas, A. Ioakimidis, V. Paschoudis
2nd Hellenic Congress of Child-Adolescent Gynaecology and
Endocrinology, Athens 6-9 December 1995

 

Pelvic infection disease and perihepatitis.T. Lainas, S. Iliadis, G. Petsas, A. Ioakimidis, I. Stathopoulos and V. Paschoudis
2nd Hellenic Congress of Infection, Athens 28-29 January 1995

 

Two years experience of a laparoscopic surgery unit at Athens Maternity hospital (video).
T. Lainas, S. Iliadis, G. Petsas, A. Ioakimidis, I. Stathopoulos and V. Paschoudis
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Laparoscopic management of ovarian cysts performed with the method of double suction using Nezhat probe without content spilage.
T. Lainas, S. Iliadis, G. Petsas, A. Ioakimidis, I. Stathopoulos and V. Paschoudis
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Hysteroscopic diagnosis and treatment of endometrial cavity pathology.
T. Lainas, S. Iliadis, V. Paschoudis, E. Hatzigiannis, A. Ioakimidis, I. Stathopoulos and B. Tzigounis
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Laparoscopic diagnosis and treatment of subtle lesions of peritoneal endometriosis.
T. Lainas, S. Iliadis, V. Paschoudis, A. Ioakimidis, I. Stathopoulos and B. Tzigounis
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Curtis-Fitz-Hugh syndrome and chlamydial pelvic infection.
T. Lainas, S. Iliadis, V. Paschoudis, A. Ioakimidis, I. Stathopoulos
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Laparoscopic treatment of ectopic pregnancy.
S. Iliadis, T. Lainas, E. Hatzigiannis, A. Ioakimidis, V. Paschoudis and I. Stathopoulos
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Laparoscopic treatment of peritoneal and ovarian endometriosis using Laser CO2.
T. Lainas, S. Iliadis, V. Paschoudis, A. Ioakimidis, I. Stathopoulos
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Referral frequency for obstetric ultrasound, pregnancy DOPPLER and biophysical profile.
I. Stathopoulos, A. Tzeferakos, I. Christopoulos and T. Lainas
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Delay of labour initiation and biophysical profile.
I. Stathopoulos, S. Iliadis, T. Lainas, V. Paschoudis and K. Gogas
6th Hellenic Congress of Obstetrics and Gynaecology, Athens 23-26 November 1994

 

Diagnosis of vaginal adenosis using the microhysteroscope Hamou II.
T. Lainas, S. Iliadis, A. Ioakimidis, V. Paschoudis, I. Stathopoulos
1st Hellenic Congress of Child-Adolescent Gynaecology and Endocrinology, Kastri, Athens 8-11 December 1993

 

Tuberculosis of the female reproductive system.
A. Komninos, E. Tsamanis, T. Lainas, M. Al-Ahmar and S. Sarris
Joint Meeting of the Greek Society of Fertility and Sterility and British Fertility Society, Rhodes 29-30 April 1983

 

Microsurgical treatment of tuboperitoneal infertility.
S. Sarris, N. Verikios, T. Lainas and A. Komninos
2nd Hellenic Congress of Perinatal Medicine, Athens 24-25 October 1981

 

Haematological changes during normal gestation.
K. Mavrelos, T. Lainas, D. Primikiris, M. Antonopoulos and A. Komninos
2nd Hellenic Congress of Perinatal Medicine, Athens 24-25 October 1981

 

The value of laparoscopy in the investigation of female infertility.
7th Hellenic Medical Congress, Athens 7-10 May 1981

 

Microsurgical treatment of female infertility.
S. Sarris, A. Komninos, T. Lainas and S. Iliadis
6th Hellenic Medical Congress, Athens 8-11 May 1980

 

Laparoscopic investigation of 270 cases of female infertility.
A. Komninos, S. Sarris and T. Lainas
6th Hellenic Medical Congress, Athens 8-11 May 1980

 

The importance of publications

The international scientific community is informed about the ongoing clinical achievements, by scientific articles (published in esteemed scientific journals). The importance of these articles and the clinical research described, is constantly assessed by 2 and/or 3 specialised scientists/professors from all around the world before these articles be published. That way they ensure that the particular article is unique and offers to the scientific community something new and innovative/pioneering.

The publication of our scientific articles, especially in internationally esteemed journals is a top honor for Eugonia's team. Our publications offer to the international scientific community new expertise  regarding the protocols for women with poor response, PCOS, polycystic ovaries. These articles, for which we are very proud, reflect the deep knowledge of the scientific field, the best scientific and technological training of our team and the constant "race"  by all the members of Eugonia( physicians, midwifes, embryologists) for an ongoing improvement regarding the  treatment referred to the couples visiting our center.